After dealing with some unexpected dryness and slight irritation from seasonal changes I decided to look for a targeted recovery serum that could support skin barrier health without being overly rich or greasy. Medicube’s PDRN Ampoule caught my eye mainly because PDRN (Polydeoxyribonucleotide) has been increasingly mentioned in skincare as a regenerative ingredient. With no previous experience using PDRN products I was curious but cautious going into the trial.

🩷Texture🩷
The texture is a clear lightweight liquid that absorbs almost instantly into the skin. It is thinner than I expected for a product marketed for skin recovery but it did not feel drying. I used about two full droppers for my entire face and neck because a single dropper felt insufficient for my needs.

💚Effects💚
There was no noticeable tingling burning or stickiness upon application which was a positive sign. However it also did not deliver a noticeable plumping or calming effect immediately after use compared to some other soothing serums I have tried.

💙Short-Term Results💙
Over two weeks of nightly use I observed that my skin felt slightly less irritated after exposure to wind and indoor heating. Redness around my nose and cheeks seemed to fade marginally faster than usual but the effect was subtle rather than dramatic.

❤️Compatibility with other products❤️

The ampoule layered well under moisturizers and sunscreens without causing pilling or heavy feeling. I appreciated that it did not interfere with makeup application the next morning.

💛Final Thoughts💛
Medicube’s PDRN Ampoule is a solid if not particularly transformative addition to a skin recovery routine. It delivers a lightweight non-irritating experience and minor improvements in skin resilience over time. However if you are expecting a major visible turnaround especially within a few weeks this product might feel underwhelming.

I would recommend it for people who want a gentle supplement to support ongoing skin repair rather than a miracle cure. Personally I am undecided about repurchasing as I feel there might be more potent options available in the same category.